Nicotinamide adenine dinucleotide (NAD+) is an important coenzyme found in cells that helps regulate many processes including cellular metabolism and energy production. It is believed that as we age, NAD+ levels decline, and that this loss contributes to aging and a number of health concerns. Therefore, researchers are interested in ways to increase NAD+ levels. Two potential precursors to NAD+ that have shown promise are NMN and NR. Several human clinical studies have shown that both NMN and NR effectively increase NAD+ in the body.

When should I take NMN?

nmn vs nr is a form of vitamin B3, also known as niacin, and occurs naturally in small amounts in foods like milk and yeast. However, it is too large to pass through cell membranes so it must first transform into NR before entering the cell. NR, on the other hand, is smaller than NMN so it can pass through cell membranes directly to begin NAD biosynthesis.

Scientists have recently identified a transporter, called Slc12a8, which is specific to NMN and allows the molecule to cross the cell barrier to enter cells. This suggests that NMN may be more efficient than NR at producing NAD+. However, more research is needed to determine whether this is true in human cells.

While both NMN and NR are effective at increasing NAD+ levels, NR is one step closer to NAD+ in the body. This is why many researchers and supplement users prefer NR supplements. When formulated in liposomes, NR is able to bypass the stomach acid and be efficiently absorbed into the bloodstream. The highest quality NR supplements in the market are formulated using this technology, such as Elysium’s Basis.

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May 6, 2023